|Treatment:||Erectile Dysfunction (ED) / Impotence|
|Daily dosage:||no more than 100mg per day|
|Take:||30-40 minutes before sexual intercourse|
|Effect of the drug:||up to 4-6 hours|
|Packing:||4 tablets in 1 strip|
|Manufactured by:||Zydus Alidac Ltd|
|Country of Origin:||India|
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Effects of Penegra-100 sildenafil citrate tablets
Penegra-100 tablets are recommended for sluggish erection and systematic premature ejaculation. The drug Penegra-100 is indicated for sexual disorder caused by diseases of the pelvic organs, hormonal failure, unhealthy lifestyle or chronic stress.
With healthy erectile function, Penegra-100 can be used occasionally in order to strengthen an erection weakened due to overwork. The drug is recommended for the complex treatment of chronic prostatitis, for the prevention of inflammatory processes of the genitourinary system and impotence, as well as as an additional therapy in the treatment of infertility.
Sildenafil, the active substance of Penigra, is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5).
The physiological mechanism of penile erection is the release of nitric oxide (NO) in the cavernous body during sexual stimulation. NO activates the enzyme guanylate cyclase, which leads to an increase in cGMP levels, relaxation of the smooth muscles of the cavernous body and increased blood flow to them. Due to the fact that sildenafil blocks PDE-5, the level of cGMP in the cavernous bodies increases, which provides relaxation of the smooth muscles of the cavernous bodies and blood flow to them. Sildenafil does not have a direct relaxing effect on the muscles of the cavernous bodies, but enhances the effect of nitrous oxide (NO) by inhibiting PDE-5, also sildenafil does not work in the absence of sexual stimulation.
In healthy volunteers, with a single use of sildenafil at a dose of 100 mg, there were no clinically significant changes on the ECG. The use of sildenafil caused a slight or moderate decrease in blood pressure (BP), which did not affect the therapeutic effect. A more significant decrease in blood pressure was observed in patients taking nitrates at the same time.
How does Penegra-100 work?
Sildenafil is absorbed fairly quickly into the blood from the walls of the stomach, starting to work 20-30 minutes after application. The synthesis of the medicinal component Penegra-100 occurs through the work of the liver. Sildenafil citrate accumulates in plasma in small amounts. The drug Penegra-100 is excreted from the body during urination.
The rate of absorption of the active ingredient is affected by fatty foods. During treatment, the patient is recommended to limit the use of high-calorie and fatty foods, as they slow down the onset of the product. Also try to stick to an active lifestyle and observe a normal water balance.
The recommended dose of Penegra-100 is 50 mg, which is used if necessary, about an hour before sexual activity. The drug can be taken within 4 hours to 0.5 hours before sexual activity. Based on efficacy and tolerability, the dosage can be increased to the maximum recommended dose of 100 mg or reduced to 25 mg. The maximum daily dose is 100 mg per day.
When taking food at the same time, the effect of Penegra-100 develops more slowly than when taken on an empty stomach. Sexual stimulation is necessary to develop the effect of the drug.
The form of release of Penegra-100 tablets
Penegra-100 is available in the form of tablets of a pale pink shade. One tablet of the drug contains 100 milligrams of the active ingredient Sildenafil. The package of Penegra-100 consists of four tablets. The drug contains Sildenafil citrate, a selective inhibitor of the enzyme PDE–5, which is responsible for the ejaculation process. The substance has a stimulating property. It increases the natural sexual arousal, causes strong physical and emotional sensations from orgasm.
Penegra-100 and alcohol
Alcohol increases the load on the liver, which processes Sildenafil, as well as the heart muscle, which actively works with sexual stimulation. As a result of the combination of Sildenafil with alcoholic beverages, the patient may feel discomfort and deterioration of well-being. An increase in blood pressure and body temperature is not excluded.
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The effect of Sildenafil is directed at the pelvic organs. The element activates blood circulation and tones the penis muscles. Under its action, the average duration of sex increases up to three times. However, taking Sildenafil has a number of limitations. https://apcalis-jelly.com First of all, the selective inhibitor is not combined with alcoholic beverages. The use of alcohol in the treatment of Sildenafil not only reduces the effectiveness of the drug by slowing down the absorption process, but also increases its concentration in plasma, which leads to prolonged and unsafe side effects.
Contraindications of Penegra-100 :
- serious pathologies of the heart and blood vessels;
- disorders of the nervous and circulatory systems;
- peptic ulcer, myeloma;
- renal or hepatic insufficiency;
- diseases in which excessive sexual activity is contraindicated for people.
Side effects of Penegra-100
Side effects of Penegra-100 occur if the rules of administration and recommended doses are not followed, as well as if there are contraindications or individual intolerance.
The most common adverse reactions of Penegra-100 include:
- redness of the face;
- spasms in the eyes;
- gastrointestinal disorder;
- nasal congestion;